AimWhite matter changes in individuals at ultra-high risk for psychosis (UHR) may be involved in the transition to psychosis. Sleep-wake disturbances commonly precede the first psychotic episode and predict development of psychosis. We examined associations between white matter microstructure and sleep-wake disturbances in UHR individuals compared to healthy controls (HC), as well as explored the confounding effect of medication, substance use, and level of psychopathology.MethodsSixty-four UHR individuals and 35 HC underwent clinical interviews and diffusion weighted imaging. Group differences on global (...) and callosal mean fractional anisotropy (FA) was tested using general linear modeling. Sleep-wake disturbances were evaluated using the subjective measures disturbed sleep index (DSI) and disturbed awakening index (AWI) from the Karolinska Sleep Questionnaire, supported by objective sleep measures from one-night actigraphy. The primary analyses comprised partial correlation analyses between global FA/callosal FA and sleep-wake measures. Secondary analyses investigated multivariate patterns of covariance between measures of sleep-wake disturbances and FA in 48 white matter regions of interest using partial least square correlations.ResultsUltra-high risk for psychosis individuals displayed lower global FA (F = 14.56, p < 0.001) and lower callosal FA (F = 11.34, p = 0.001) compared to HC. Subjective sleep-wake disturbances were significantly higher among the UHR individuals (DSI: F = 27.59, p < 0.001, AWI: F = 36.42, p < 0.001). Lower callosal FA was correlated with increased wake after sleep onset (r = −0.34, p = 0.011) and increased sleep fragmentation index (r = −0.31, p = 0.019) in UHR individuals. Multivariate analyses identified a pattern of covariance in regional FA which were associated with DSI and AWI in UHR individuals (p = 0.028), but not in HC. Substance use, sleep medication and antipsychotic medication did not significantly confound these associations. The association with objective sleep-wake measures was sustained when controlling for level of depressive and UHR symptoms, but symptom level confounded the covariation between FA and subjective sleep-wake measures in the multivariate analyses.ConclusionCompromised callosal microstructure in UHR individuals was related to objectively observed disruptions in sleep-wake functioning. Lower FA in ventrally located regions was associated with subjectively measured sleep-wake disturbances and was partly explained by psychopathology. These findings call for further investigation of sleep disturbances as a potential treatment target. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Return of Scepticism: From Hobbes and Descartes to BayleSébastien CharlesGianni Paganini, editor. The Return of Scepticism: From Hobbes and Descartes to Bayle. Dordrecht: Kluwer, 2003. Pp. xxviii + 486. Cloth, $180.00.Cette édition des actes du congrès international « The Return of Scepticism », organisé par Gianni Paganini à l'Université du Piémont-Oriental de Vercelli en mai 2000, a pour ambition de faire le point sur l'état de la (...) recherche actuelle en cherchant à cerner au mieux les implications épistémologiques et les répercussions européennes du scepticisme à la période moderne. Placés sous le patronage de Richard H. Popkin, dont un essai ouvre l'ouvrage et pave la voie à de futures recherches sur la question, les textes rassemblés par Gianni Paganini ont pour trait commun d'insister sur la prégnance du scepticisme à l'époque moderne, tout en prenant garde au fait de bien replacer chaque stratégie sceptique dans l'environnement culturel et philosophique qui fut le sien. Divisé en sept sections, l'ouvrage fournit une vue d'ensemble de la question sceptique qui s'étale sur deux siècles, le XVIIe et le XVIIIe.Dans la première section, l'accent est mis sur un aspect délaissé de l'histoire du scepticisme moderne, à savoir le traitement particulier qui lui fut réservé dans la pensée anglaise des XVIIe et XVIIIe siècles. Sont abordés ici les cas de Hobbes, dont le traitement du scepticisme est pensé en relation inversée avec celui de Descartes (G. Paganini), Locke, qui tend à faire sien le principe sceptique de la limitation du savoir (G. A. J. Rogers), et les Platoniciens de Cambridge, qui s'inspirent de la méthode sceptique pour compartimenter le champ du savoir (F. Tomasoni).Dans la deuxième section, c'est la pensée continentale qui est à l'honneur, avec des textes consacrés à Descartes spécifiquement ou à La Mothe le Vayer et Descartes, avec pour objectif commun de questionner l'originalité du travail cartésien en insistant notamment sur le rôle de l'epoché chez Charron comme source possible du cogito (J. R. Maia Neto) et sur une tradition sceptique non fidéiste présente dans les œuvres de La Mothe le Vayer comme de Descartes (J.-P. Cavaillé).La troisième section évoque la prise de conscience des enjeux sceptiques chez les sectateurs et les adversaires de Descartes, qui s'accordent tous à reconnaître l'insuffisance de la réfutation du scepticisme proposée par ce dernier. Ce point fait l'unanimité tant chez les opposants à Descartes—Martin Schoock (A. Del Prete), Pierre Villemandy (C. Borghero), Pierre-Daniel Huet (T. M. Lennon), et les philosophes italiens Fardella et Doria (M. T. Marcialis)—que chez ceux qui se sont inspirés de sa philosophie—Arnauld (G. Belgioioso), Malebranche, Foucher et Desgabets (E. Scribano).La prise en compte des enjeux sceptiques aux plans politique et religieux est intégrée dans la quatrième partie au sein de laquelle sont évoquées des thématiques plurielles comme la présence du probabilisme néo-académique chez Pascal (A. McKenna), l'interprétation sceptique, voire libertine, du pouvoir et de la liberté rattachée à la théorie hobbesienne de l'état de nature chez Samuel Sorbière (L. Bianchi), ou le rapport existant entre scepticisme et tolérance (L. Simonutti).La section suivante délaisse politique et religion pour aborder le cas de la science, et de l'effet du scepticisme au niveau épistémologique. Le cas de Martín Martínez témoigne du fait que le scepticisme peut être conciliable avec une vision empiriste de la science et qu'une physique sceptique reste possible (J. C. Laursen). De même, le rapport des savants italiens comme Redi, Magalotti ou Dati à l'égard du scepticisme est évocateur de la prise de conscience des dangers que le scepticisme pose pour le domaine du démontrable (M. Torrini), ce qui vaut également pour toute théorie de la signification, dont les implications sceptiques sont patentes (G. Hassler), ou pour toute approche historique minée par des considérations pyrrhoniennes (C. Grell... (shrink)

THE PARADOXES OF CONFIRMATION ARE CONSTITUTED BY THE CONTRADICTIONS ARISING FROM THE CONJUNCTION OF THREE PRINCIPLES OF CONFIRMATION - NICOD’S CRITERION, THE EQUIVALENCE CONDITION, AND WHAT THE PAPER CALLS THE SCIENTIFIC LAWS CONDITION. THE PAPER DISCUSSES IN DETAIL THE VARIOUS SOLUTIONS PROVIDED BY ABANDONING ONE OF THE PRINCIPLES. IN THE END IT FINDS NICOD’S CRITERION FALSE, BUT FINDS THE EXPLANATIONS GIVEN BY H.G. ALEXANDER AND OTHERS OF WHY NICOD’S CRITERION IS FALSE THEMSELVES UNSATISFACTORY. IT THEN PROVIDES A MORE ADEQUATE ACCOUNT (...) OF THE CIRCUMSTANCES IN WHICH "RA.BA" CONFIRMS "ALL R’S ARE B". (shrink)

The essays in this volume are by fellow historians of ideas and philosophy, colleagues, and former students of Richard Popkin; its editor is his son, a historian at the University of Kentucky. The volume is in the style of a festschrift, but it has a special personal component. The notes on the contributors indicate how each came to know Popkin. The essays do not concentrate on developments of each author’s own work, but access Popkin’s work, in some instances extending it, (...) and often relating it to aspects of his career. The final contribution is a biographical sketch of his career, done by the editor, from letters that are part of Popkin’s papers housed in the Clark Library at UCLA. This biographical sketch is preceded by a memoir by Avrum Stroll, recounting his collaboration with Popkin on their Philosophy Made Simple, which they co-authored in 1955 and which, in its multiple printings, has served as an introductory textbook for generations of students.The fourteen essays are by B. Copenhaver, A. P. Coudent, S. Hutton, P. K. J. Park, and K. Peden ; J. E. Force, M. Mulsow, and D. B. Ruderman ; J. C. Laursen, J. R. Maia Neto, and G. Paganini ; and Y. Kaplan, D. S. Katz, and M. Goldish. (shrink)

We generalize two well-known model-theoretic characterization theorems from propositional modal logic to first-order modal logic. We first study FML-definable frames and give a version of the Goldblatt–Thomason theorem for this logic. The advantage of this result, compared with the original Goldblatt–Thomason theorem, is that it does not need the condition of ultrafilter reflection and uses only closure under bounded morphic images, generated subframes and disjoint unions. We then investigate Lindström type theorems for first-order modal logic. We show that FML has (...) the maximal expressive power among the logics extending FML which satisfy compactness, bisimulation invariance and the Tarski union property. (shrink)

The essays in this volume are by fellow historians of ideas and philosophy, colleagues, and former students of Richard Popkin; its editor is his son, a historian at the University of Kentucky. The volume is in the style of a festschrift, but it has a special personal component. The notes on the contributors indicate how each came to know Popkin. The essays do not concentrate on developments of each author’s own work, but access Popkin’s work, in some instances extending it, (...) and often relating it to aspects of his career. The final contribution is a biographical sketch of his career, done by the editor, from letters that are part of Popkin’s papers housed in the Clark Library at UCLA. This biographical sketch is preceded by a memoir by Avrum Stroll, recounting his collaboration with Popkin on their Philosophy Made Simple, which they co-authored in 1955 and which, in its multiple printings, has served as an introductory textbook for generations of students.The fourteen essays are by B. Copenhaver, A. P. Coudent, S. Hutton, P. K. J. Park, and K. Peden ; J. E. Force, M. Mulsow, and D. B. Ruderman ; J. C. Laursen, J. R. Maia Neto, and G. Paganini ; and Y. Kaplan, D. S. Katz, and M. Goldish. (shrink)

An algebraic semantics, based on factor algebras, for one-way and two-way implicative verbs is proposed. Implicative verbs denote elements of filters or of ideals generated by identity functions in factor algebras. This semantics explains in particular the problem of implicational equivalence raised by two-way implicative verbs, and shows that the negation necessary to establish the implicativity of these verbs is the negation which preserves the presuppositions of sentences with implicative verbs. In addition, it follows from the proposed semantics that any (...) two implicative verbs denoting in the same algebra but belonging to different categories, are semantically related. (shrink)

The problems and the history of contacts between distant continents in bygone ages and long before the age of fast and easy travel, have always fascinated both professional scholars and the interested public. Was ancient history really nothing but the history of co-existing and isolated geographic, cultural and political “islands?” Already at school we learned too much about migrations of peoples, economic contacts, influences on art styles, conquests, and the rise, expansion and fall of empires to believe that. The (highly (...) improbable) theory that certain archaeological finds in America suggest, or even prove, Mediterranean influence (e.g., the arrival of Phoenician ships), or the alleged Viking discovery of America centuries before Columbus, or Thor Heyerdahl's adventurous journey to prove South American influence on remote Pacific islands did not fail to cause widespread interest and even excitement (although many scholars still feel that Heyerdahl's epic adventure, thrilling as it is, failed to prove what it set out to prove). The island of Madagascar is pretty close to the African continent, but its language exhibits more points of contact with Polynesian than with African tongues. And the blow-bellows used by Malagache smiths are similar to those used in Malaysia and unlike those known to African metalworkers. Clearly the Polynesians, those great ancient mariners, sailed further than originally seemed likely. Musicologists studying the cantillation of the Hebrew Bible in the liturgy of the ancient Jewish communities on the Malabar coast in India discovered to their surprise that it was similar to the cantillation not of the Babylonian but of the Yemenite Jews! This surprise was, of course, no surprise to those who knew anything about trade-winds and shipping routes between South Arabia and the Indian coast. Historians of religion, even more than general historians, studying the spread and expansion of religious ideas and movements have realised long ago that the beginning of all wisdom is a basic knowledge of economic geography. (shrink)

Arvind Thomas has written a remarkable book. That said, however, it must be quickly added that it is not a book for everyone, not even for all students of medieval literature. It is a very thoughtf...

The aim of this paper is to understand the philosophical role of Collingwood’s proposed logic of question and answer. I shall consider its historical background as a response to Bradley, to the “realists” and to the logical positivists. I shall also consider the similarities and differences between it and modern developments in logics of question and answer and also in anti-realist philosophical logic. In analysing Collingwood’s proposed logic, and its potential for development, I shall attempt a sketch of how it (...) would work out in formal terms. To be sure Collingwood dismissed the symbolism of Russell and Whitehead’s Principia Mathematica as “typographical jargon” and he thought the various artificial logical languages of his time to be “numerous and frightful offspring of propositional logic out of illiteracy”. Nevertheless he did recognise an important role for the logician in articulating his system, namely to identify what it is to be a proposition and what it is to be a question and in doing so to identify what constitutes an “absolute presupposition”. Moreover since Collingwood’s day there have been important developments in logic and semantics, which are expressed through typographical jargon, and yet which are highly relevant to Collingwood’s proposed logic and to its philosophical role. (shrink)

Book Information Self-Governance and Cooperation. By Robert H. Myers. Oxford University Press. Oxford. 1999. Pp. vi + 179. Hardback, £30.00.

As everyone knows, since the end of the Second World War there has been a sensational revival of interest in the non-Christian religions particularly in the United States and in this country. The revival has taken two forms, the one popular, the other academic. The first of these has turned almost exclusively to Hindu and Buddhist mysticism and can be seen as an energetic reaction against the dogmatic and until very recently rigid structure of institutionalised Christianity and a search for (...) a lived experience of the freedom of the spirit which is held to be the true content of mysticism, obscured in Christianity by the basic dogma of a transcendent God, the ‘wholly Other’ of Rudolf Otto and his numerous followers, but wholly untrammelled by any such concept in the higher reaches of Vedanta and Buddhism, particularly in its Zen manifestation. On the academic side the picture is less clear. There is, of course, the claim that the study of religion, like any other academic study, must be subjected to and controlled by the same principles of ‘scientific’ objectivity to which the other ‘arts’ subjects have been subjected, to their own undoing. But even here there would seem to be a bias in favour of the religions of India and the Far East as against Islam, largely, one supposes, in response to popular demand. (shrink)

Regarded as a revisionist historian in the West, Patricia Crone, who wrote many books and articles on various subjects of early Islamic history, was a prolific researcher. The place and role of mawālī, in the Umayyad and Abbāsid society, has been one of the special topics she has been interested in since the very beginning of her academic life. Her works with a revisionist perspective have been faced many criticisms by colleagues, especially the western ones, because of her biased view (...) of the sources written by Muslim authors, her methodology, and her results. However, it is obvious that Crone’s studies on mawālī have positively or negatively affected the Eastern and Western academics in Islamic studies. This article’s main purpose is to reveal Crone’s views on mawālī in Isla-mic society and draw an outline without comment as much as possible. The paper consists of three parts. In the first part, Crone’s revisionist perspective and her works on mawālī have been explained. In the second part, her distinctive views on the mawālī and its origin have been discussed. Finally, in the third part, her findings of the position of mawālī in social, political, military, and economic life during the Rāshidun Caliphs, the Umayyads, and the Abbāsids have been introduced. This study, which tackles Crone’s views on mawālī, aims to encourage the further studies on this subject. (shrink)

Kur’an’ın kendine has birbiriyle irtibatlı kelimeler dünyası bulunmakta-dır. Doğru bir Allah tasavvuru, Allah-âlem, Allah-kul, âlem-kul ilişkisinin nasıl olması gerektiği bu kelime dünyası tarafından anlatılmaktadır. Bu nok-tada Kur’an’da herhangi bir konu anlatılırken aralarında sıkı irtibat olan kelime grupları kullanılmıştır. Örneğin Allah Kur’ân’da kendisini, Rakîb, Alîm, Basîr, Habîr, Latîf vb. lafızlarla insanın idrakine yansıtmakta ve böylece doğru bir Allah Tasavvuru oluşmasını amaçlamaktadır. Bu çalışmada, öncelikle ra-ka-be /رقب kökünün etimolojisi üzerinde durulacaktır. Zira bir kelimenin dildeki asli anlamı ve türevleriyle beraber sonradan kazandığı anlamların (...) tespiti, ilgili kelimenin anlam sahasını keşfetme ile mümkündür. Akabinde bu kökün türevlerinden “Rakîb” kelimesi ile anlam ilişkisi olan ve Yüce Allah’ın Kur’ân’da kendisine nispet ettiği sıfatlarından, Alîm, Basîr, Habîr, Şehîd kelimeler tahlil edilecektir. Bu bağlamda doğrudan olmasa da dolaylı olarak Allah’ın görmesini ve gözetlemesini ifade eden kelimelere ve ilgili âyetlere yer verilecektir. Böylece ra-ka-be kökünün Kur’an siyakındaki anlam sahası ortaya konulmuş olacaktır. (shrink)

The time taken to react voluntarily to a stimulus is far longer than can be accounted for by ordinary processes of nerve conduction and synaptic delay, and varies unpredictably from trial to trial. Though random, the distribution of reaction times usually follows a relatively simple law, which in turn can be explained by the LATER model, in which a decision signal, representing belief in the existence of the target, rises in response to incoming sensory evidence from an initial value to (...) a criterion level at which action is initiated. But the rate of rise fluctuates randomly from trial, to an extent that cannot be explained by sensory noise at the input. These conclusions, confirmed by recording from neurons in the frontal eye fields, suggest that the randomness of reaction time is due to a deliberate, gratuitous, neural process which confers certain biological advantages as well as having implications for general ideas about the nature of ‘free will'. (shrink)

Establishing acceptable norms of behavior and consistent standards of conduct has been part of the human enterprise since the dawn of time. Without principles of ethics and the moral rules that affect individual behavior, humankind would plunge into a state of chaotic indifference, insecurity, and unending fear. But while few question the need for moral guidance, a growing number of people believe that the only ethic worth considering must rest on a biblical foundation. Is morality dependent upon God and "revealed (...) truths" found in scripture? Must this claim be accepted without question lest we risk the torment of eternal damnation for questioning it? Without critical evaluation and careful scrutiny, there is little hope of distinguishing truth from unfounded belief. How valuable is the Bible as a source for ethical truth? Do the scriptures truly have the insight needed to guide humankind safely through the moral dilemmas of modern society? What constitutes a biblical ethic? Should the Bible be construed as the only basis for moral teaching? Is it really the final authority on moral issues, or are there secular alternatives that can serve as guides to acceptable conduct within the human community? A distinguished group of social philosophers, biblical scholars, and ethicists met at the University of Richmond, Virginia, under the aegis of the Committee for the Scientific Examination of Religion and its Biblical Criticism Research Project, to address these and related questions. The essays in this provocative work demonstrate a diversity of perspective and breadth of insight that will shed much needed light on the nature of ethics. The contributors to this volume include: Robert S. Alley, Joe Edward Barnhart, Joseph L. Blau, Frank E. Eakin, Jr., Lewis S. Feuer, Joseph Fletcher, Theodor H. Gaster, James H. Hall, R. Joseph Hoffmann, Paul Kurtz, Gerald A. Larue, John Priest, Ellis Rivkin, Richard L. Rubenstein, and Richard Taylor. (shrink)